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Special searchlight for diabetes Insulins: Soliqua 100/33 (insulin glargine / lixisenatide)

Starting dose - Soliqua

Lindsay Slowiczek, PharmD's Medical Assessment, April 5, 2019. Written by Victor Nguyen, PharmD, MS.

DLife has a particular partnership that has brought our readers an informative new collection of several types of insulin by way of the Healthcare Medical Network

We hope this collection is beneficial. Healthline has made each effort to ensure that all info is definitely right, complete and updated

This article shouldn’t, nevertheless, exchange the information and experience of a licensed healthcare professional. 19659002] It is best to all the time consult your physician or well being care skilled before taking any drugs.

Contents

What is Soliqua 100/33?

Soliqua 100/33 is a model identify prescription drug. Soliqua 100/33 incorporates two medicine:

  • insulin glargine, a long-acting insulin
  • lixisenatide, belonging to at least one group of medicine referred to as a glucagon-like peptide 1 (GLP-1) receptor agonist

Soliqua 100/33 is an injectable pen used for self-administration underneath the pores and skin (subcutaneous). Every pen accommodates 3 ml of the drug answer, 100 models of insulin glargine and 33 mcg of loxysatide per ml of answer.

Efficacy

Soliqua 100/33 has been shown to be efficient in the remedy of sort 2 diabetes. In a single medical research, Soliqua 100/33 was examined in sufferers with sort 2 diabetes handled with long-acting insulin for at the very least six months. After 30 weeks of remedy with Soliqua 100/33, these individuals had a lower in hemoglobin A1c (HbA1c) by 1.1%. Additionally they had a decreased blood sugar degree of 5.7 mg / dl.

In another medical research, Soliqua 100/33 was used with metformin for 30 weeks. The research included people who had beforehand acquired remedy with metformin alone or with metformin and another oral antidiabetic drugs. Remedy with Soliqua 100/33 and metformin lowered HbA1c by 1.6%. It additionally lowered the fasting blood sugar degree by 59.1 mg / dl.

Soliqua 100/33 Basic

Soliqua 100/33 is just obtainable underneath the model identify. Soliqua 100/33 accommodates two lively medicines: insulin glargine and loxincatide.

Insulin glargine is a long-acting insulin out there alone beneath the model identify, comparable to Lantus, Toujeo and Basaglar. Lixisenatide belongs to a gaggle of medicines referred to as glucagon-like peptide-1 (GLP-1) receptor agonists.

Dosage of Soliqua 100/33

Usually, your physician will start a small dose of Soliqua 100/33 and regulate it over time to realize the fitting dose for you. This adjustment course of is known as titration. Your physician will finally prescribe the bottom dose that will provide you with the desired impact.

The following info describes generally used or advisable doses. Nevertheless, ensure you take the dose prescribed by your doctor. Your doctor will decide the most effective dose in accordance with your needs.

Drug Shapes and Strengths

Every Soliqua 100/33 pack accommodates five disposable, pre-filled Soliqua 100/33 injection pens within the carton. The pen needles don’t come with a pen. (Typically, you should purchase pen needles in a pharmacy. You might need a prescription.)

Each pen accommodates 3 ml of the drug answer, a total of 300 models of insulin glargine and 100 mcg of loxysatide. 19659008] Soliqua 100/33 injectable pens are designed to be used a number of occasions. The one-time period might differ from 5 to 20 occasions relying on the dose. Every pen can be utilized for 28 days after initial use. You need to then eliminate the pen even when it nonetheless incorporates some drugs.

Pen needles ought to only be used as soon as.

Dosage for Soliqua 100/33

Soliqua 100/33 is usually prescribed for single injections, every of 15 to 60 models. The term "units" is the measurement of insulin glargine in Soliqua 100/33. The utmost dose per injection is 60 models, which suggests 60 models of insulin glargine and 20 mcg of lxisenatide

Preliminary dose

The really helpful beginning dose for Soliqua 100/33 depends upon your previous diabetes remedy

Observe: Before you start Soliqua 100/33, it’s essential to cease all different remedies with loxincatide or long-acting insulin.

Upkeep dose

After starting Soliqua 100/33, your physician will monitor your blood sugar degree and should regulate your dose to get the correct quantity for you. The drug producer recommends raising the dose upwards or downwards from 2 to 4 models every week to realize blood glucose targets

Dose adjustment

You and your doctor will work collectively to realize a blood sugar plan

Under is an instance of dose adjustment your physician might advocate. Your doctor will determine in the event you need these modifications. Keep in mind to take the dose beneficial by your physician. (Do not change your dose without your physician's approval.)

 Dose adjustment Soliqua

What if I miss a dose?

When you miss a dose of Soliqua 100/33, skip this dose and proceed with the subsequent dose. Don’t attempt to catch up by taking an additional dose or by adding the subsequent dose. This will cause dangerous unwanted side effects

Do I want this drugs in the long run?

If Soliqua 100/33 is efficient and protected for you, you’re probably to make use of this drugs in the long term. Soliqua 100/33 is usually used for long-term remedy of sort 2 diabetes.

Unwanted effects of Soliqua 100/33

Soliqua 100/33 may cause delicate or extreme unwanted side effects. The following record accommodates a number of the key unwanted effects which will happen during remedy with Soliqua 100/33. This record does not have all the attainable negative effects.

For more info on potential unwanted side effects of Soliqua 100/33 or recommendations on tips on how to cope with a problematic aspect effect, see your doctor or pharmacist.

The most typical negative effects of

The extra widespread unwanted effects of Soliqua 100/33 may be:

  • nausea
  • respiratory infections comparable to widespread cold or flu
  • diarrhea
  • headache
  • hypoglycemia (low) blood sugar)

Most of these uncomfortable side effects might disappear after a couple of days or a few weeks. If they are extra critical or do not go away, contact your physician or pharmacist.

Critical negative effects

Critical negative effects of Soliqua 100/33 usually are not widespread, however they could occur. Call your doctor instantly when you’ve got critical unwanted effects. Call 911 in case your signs are life-threatening or for those who assume you’re in an emergency.

Critical uncomfortable side effects and their signs might embrace:

  • Extreme allergic response. Signs might embrace:
    • rash
    • rinsing
    • swelling
    • itchy skin
    • problem respiration
    • low blood strain
  • Pancreatitis (irritation of the pancreas). Symptoms might embrace:
    • ache or sensitivity to your stomach
    • again pain
    • nausea
    • vomiting
    • fever
    • weight reduction
  • Kidney injury. Signs might embrace:
    • decreased urination
    • swelling of legs, ankles or legs
    • confusion
    • fatigue
    • nausea
    • chest ache or strain
    • irregular heart beat
  • Hypokalemia (low potassium). Symptoms might embrace:
    • weak spot
    • fatigue
    • constipation
    • muscle spasm
    • irregular heartbeat

Weight achieve or weight reduction

In medical trials, Soliqua 100/33 was not found to trigger weight reduction. In a single medical research, people who took Soliqua 100/33 for 30 weeks lost about 1.5 pounds.

In addition, the person medicine contained in Soliqua 100/33 are related to weight modifications. Soliqua 100/33 accommodates insulin glargine, a long-acting insulin. Medicines containing insulin might cause weight achieve

Soliqua 100/33 additionally accommodates loxysatide, a glucagon-like peptide 1 (GLP-1) receptor agonist. In a number of medical trials, medicine within the GLP-1 class have shown a aspect effect of weight reduction.

In case you are involved about weight loss while taking Soliqua 100/33, speak to your doctor.

Hypoglycemia [19659030] Insulin, one of many medicines of Soliqua 100/33, is used to lower blood sugar ranges. Nevertheless, your blood sugar degree could also be decreased too far, leading to hypoglycaemia. Hypoglycaemia is the most typical aspect impact of insulin medicines, Soliqua 100/33.

In medical trials, hypoglycaemia occurred in Eight.1 to 17.Eight% of sufferers taking Soliqua 100/33. And about 1% of people who took the drugs had extreme hypoglycaemia.

Many elements might improve the danger of hypoglycaemia. These embrace, for instance, taking larger doses of the antidiabetic drug and using multiple antidiabetic drug. Different dangers which will have an effect on the dangers are eating and exercise and are taking different medicines.

The symptoms of hypoglycaemia might occur abruptly and should embrace shaking, fatigue, drowsiness and confusion. Severe hypoglycaemia may cause critical unwanted side effects comparable to seizures or even demise. Speak to your physician about how typically that you must examine your blood sugar degree to stop hypoglycaemia during remedy with Soliqua 100/33.

Melancholy or thickened pores and skin

Soliqua 100/33 is given by injection underneath the skin, which signifies that you inject it beneath. your skin. Subcutaneous injection might cause lipodystrophy (melancholy or thickening of the pores and skin) around the injection website.

To be able to scale back the danger of lipodystrophy, alternate sites for injecting the drug. For instance, someday you may inject your drugs into your stomach and subsequent you should use your outer thigh.

In case you are concerned concerning the pores and skin effects of injecting Soliqua 100/33, speak to your doctor. [19659029] Kidney injury

No kidney injury was noticed in medical studies with Soliqua 100/33. Nevertheless, kidney injury has been reported in people who have acquired glucagon-like peptide 1 (GLP-1). Lixisenatide, one of many medicines of Soliqua 100/33, is a GLP-1 drug

Symptoms of kidney injury might embrace:

  • swelling of the legs, ankles or legs
  • fatigue
  • nausea
  • vomiting
  • vomiting
  • vomiting [19659009] Kidney injury sometimes occurred in individuals who had turn into dehydrated because of sure negative effects of Soliqua 100/33, resembling nausea, vomiting and diarrhea.

    If these symptoms occur during using Soliqua 100.

Soliqua 100/33 prices

The cost of Soliqua 100/33 can differ with totally different medicines. Discover the current prices of Soliqua 100/33 in your area, take a look at GoodRx.com.

The worth you pay on GoodRx.com is what you pay with out insurance. Actual prices depend upon insurance coverage protection.

Financial and Insurance coverage Help

In case you need monetary help to pay for Soliquan 100/33, help is obtainable. Soliqua 100/33 by Sanofi Aventis provides Soliqua 100/33 Savings Card. See the program web site for more info

Under are some primary instructions for giving your Soliqua 100/33 injection. All the time pay attention to Soliqua 100/33 as directed by your doctor or healthcare provider

How you can give

Step 1. Prepare and examine your pen

If this is your first use, take the pen out.

  • Gather alcohol wipes, a new needle and a pointy disposal container.
  • Wash your arms.
  • Remove the pen cap and make sure the medicine is obvious and has no colour. (Do not use if the answer shouldn’t be clear and colorless. Air bubbles are ok.)
  • Clean the rubber seal with an alcohol wipe

Step 2. Attach a new pen needle.

All the time Use a brand new pen needle. Ensure the pen needle can be used with Soliqua 100/33. In the event you do not know what needles are used, ask your doctor or pharmacist.

  • Remove the pen needle from its protective packaging
  • Maintain the pen needle straight, twist it into the pen. pen needle cover and set it apart. (Retailer after injection.)
  • Take away the inside needle defend and discard it in the trash.

Step 3. Perform a security check

All the time make a safety check before every injection. pen and needle work correctly

  • Regulate the dose counter to read 2 models
  • Press the injection button utterly and examine that there is little drug answer on the tip of the needle. If this occurs, go to step 4.
  • If not, repeat the security check as much as 3 times.
  • If the drug does not come after three checks, substitute the needle and repeat the security checks. ] If the drugs doesn’t come after changing the needle, don’t use the pen as it might be broken. Use a brand new pen

Step 4. Choose a dose

  • Flip the dose counter till you reach the required dose.

Step 5. Injection Dose

The body has three areas. can be utilized on the injection website: stomach (besides for 2 inches of stomach button), upper again (fats area) and outer thigh.

  • Choose an injection website and wipe the pores and skin
  • On the injection website, place the needle on the pores and skin at a 90 diploma angle
  • Press and hold the injection button all the best way down till "0" is displayed within the dose window
  • When the dose counter turns to "0", calculate 10: before releasing the injection button and eradicating the needle. This break will help ensure you get the complete dose.
  • Release the injection button and take away the needle from the skin

Step 6. Discard the needle and retailer the pen.

  • Remove the needle from the injectable pen and immediately eliminate the needle in a pointy container. (Eliminate it immediately to avoid mixing it with a new needle.)
  • Put the pen cap back on the pen.
  • Retailer the pen at room temperature after the primary use.
  • Timing

    take Soliqua 100/33 hours before the first meal

    Taking Soliqua 100/33 with meals

    Soliqua 100/33 shouldn’t be taken with food.

    Options to Soliqua 100/33

    Other drugs can be found that may deal with sort 2 diabetes. Some may be more appropriate for you than others. In case you are serious about finding an alternative choice to Soliqua 100/33, speak to your physician to study extra about different medicines which will work properly for you.

    Soliqua 100/33 accommodates two medicine: long-acting insulin glargine insulin. and glucagon-like peptide 1 (GLP-1) receptor agonist, referred to as lixisenatide

    Examples of medicine that can be used as an alternative choice to Soliqua 100/33 are:

    • long-acting insulin, comparable to:
      • insulin glargine (Lantus, Toujeo)
      • insulin detemir (Levemir)
    • GLP-1 receptor agonists, akin to:
      • exenatide (Bydureon, Byetta)
      • liraglutide (Victoza, Saxenda)
      • loxysatide (adlyxin)
      • semaglutide (Ozempic)
    • dipeptidyl peptidase-4 (DPP-4) inhibitors, corresponding to:
      • alogliptin (Nesina)
      • linagliptin (Tradjenta)
      • saxagliptin (Onglyza)
      • sitagliptin (Januvia)
    • meglitinides, akin to:
      • repaglinide (Prandin)
      • nateglinide (Starlix)
      • metformin (Glucophage, Glumetza, Riomet)
    • inhibitors of sodium glucose-cotransporter 2 (SGLT2), similar to:
      • canagliflozin (Invokana)
      • dapagliflozin (Farxiga)
      • empagliflozin (Jardiance)
    • sulfonylureas, similar to:
      • glimepiride (amaryl)
      • glipizide (glucotrol)
      • glyburide (DiaBeta, Glynase)
    • thiazolidinediones, resembling:
      • pioglitazone (Actos)
      • rosiglitazone (Avandia)

    Soliqua 100/33 vs. Xultophy

    You could marvel how Soliqua 100/33 compares to different medicine prescribed for comparable makes use of. Here's how Soliqua 100/33 and Xultophy are alike and totally different.

    Operation

    Soliqua 100/33 and Xultophy are each FDA-approved to improve blood glucose levels in adults with sort 2 diabetes. They’re both prescribed for use with dietary modifications and train.

    Soliqua 100/33 and Xultophy include each medicine, and these medicine belong to the identical drug teams. Because of this they work in the same method within the physique

    Soliqua 100/33 incorporates:

    • insulin glargine (long appearing insulin)
    • lixisenatide (glucagon-like peptide 1 [GLP-1] receptor agonist)

    Xultophia accommodates:

    • insulin degludek (long-acting insulin)
    • liraglutide (GLP-1 receptor agonist)

    Types and Administration of Medicines

    Soliqua 100/33 and Xultophy are a liquid answer for a disposable injectable pen.

    Unwanted effects and risks

    Soliqua 100/33 and Xultophia have comparable effects on the physique and thus have very comparable negative effects.

    Most Widespread Aspect Results

    This listing offers examples of extra widespread unwanted side effects which will happen with each medicines (taken individually).

    • Can happen with both Soliqua 100/33 and Xultophy:
      • respiratory infections resembling widespread cold or flu
      • nausea
      • diarrhea
      • headache
      • hypoglycemia (low blood sugar)

    Critical negative effects

    These lists embrace examples of great uncomfortable side effects might occur with Soliqua 100/33 , Xultophia, or each (when taken individually).

    • Soliqua 100/33 can happen:
      • Some Distinctive Critical Aspect Results
    • Might Occur With Xultophia:
      • thyroid most cancers *
      • gallbladder disease
    • Can occur with both Soliqua 100/33 and Xultophy:
      • extreme allergic response
      • extreme hypoglycemia (severe low blood sugar)
      • pancreatitis (pancreatitis)
      • kidney injury
      • hypokalemia (low potassium degree)

    * Xultophia has a FDA-triggered supply of thyroid most cancers. Enclosed Warning is the strongest warning the FDA requires.

    Efficacy

    Soliqua 100/33 and Xultophy haven’t been in contrast immediately in medical trials, but both have been proven to be efficient in the remedy of sort 2 diabetes.

    In separate research, Soliqua 100/33 and Xultophy have been both efficient in decreasing each HbA1c and fasting blood ranges.

    • In a medical research, Soliqua 100/33 lowered hemoglobin A1c (HbA1c) by 1.1% and fasting sugar. 5.7 mg / dl after 30 weeks of remedy
    • In medical trials, Xultophy decreased HbA1c by 1.31 to 1.94% and fasting to 49.9 mg / dl to 63.5 mg / dl after 26 weeks of remedy. Individuals taking Xultophia also acquired about 4.Four kg of remedy over 26 weeks.

    Word: It is very important keep in mind that every of these medicine lowers the extent of HbA1c or blood sugar depending on many elements, similar to: 19659008] how intently you comply with the remedy program

    Value

    Soliqua 100/33 and Xultophy are each brand names. There are presently no widespread varieties out there in either drug. Brand medicine usually value greater than generic medicine.

    Based mostly on GoodRx.com estimates, Xultophy can value more than Soliqua 100/33. The actual worth you’d pay for a drug will rely on your dose, your insurance coverage plan, your location and the pharmacy you’re using.

    Soliqua 100/33 vs. different medicine

    In addition to Soliquan 100, there are other medicine. 33 and Xultophy (supra) which can be used to deal with sort 2 diabetes. Under is a comparability between Soliqua 100/33 and a number of other other medicine

    Soliqua 100/33 vs. Lantus

    Soliqua 100/33 accommodates two medicine:

    • insulin glargine, a long-acting insulin
    • lixisenatide which belongs to a gaggle of medicines referred to as glucagon-like peptide-1 (GLP-1) receptor agonists

    Glargine insulin is a drugs contained in Lantus. Because Soliqua 100/33 and Lantus use the lively ingredient, they work the identical approach in the physique.

    Operation

    Soliqua 100/33 is FDA-approved for use in dietary modifications and workouts to improve blood sugar ranges in adults

    Lantus is FDA-approved to improve blood glucose ranges in adults and youngsters with sort 1 diabetes and adults with sort 1 diabetes. 2 diabetes.

    Formulations and Administration of Medicine

    Soliqua 100/33 turns into a liquid answer in a disposable pen. Lantus is a liquid answer in a multi-dose vial or disposable pen. Each medicine are injected beneath the skin (subcutaneous) once a day

    Unwanted effects and risks

    Soliqua 100/33 and Lantus include both the identical long-acting insulin, insulin glargine. Subsequently, each medicine may cause very comparable uncomfortable side effects. Under are some examples of those uncomfortable side effects. 19659048] Might occur with Soliqua 100/33:

    • nausea
    • respiratory infections, reminiscent of widespread cold or flu
    • headache
    • diarrhea
  • Might happen with Lantus:
    • lipodystrophy (skin recess or thickening on the injection website)
    • injection website reactions

  • Might occur with each Soliqua 100/33 and Lantus:
    • hypoglycemia (low blood sugar)
  • Critical Aspect Results

    These lists embrace examples of great unwanted effects which will occur with Soliqua 100/33, Lantus, or both (taken individually)

    • . / 33:
      • pancreatitis (pancreatitis)
      • kidney injury
    • Might occur with Lantus:
      • Some Distinctive Critical Aspect Results
    • Might occur with both Soliqua 100/33 and Lantus:
      • severe allergic reaction
      • severe hypoglycemia (extreme low blood sugar)
      • low potassium (hypokalemia)

    Efficacy

    The efficacy of Soliqua 100/33 and Lantus has been instantly in contrast in two studies. In the first research, each medicines have been used alone. In certainly one of them, each have been utilized in combination with metformin (an oral antidiabetic drugs).

    Plain Use

    The primary research targeted on adults with sort 2 diabetes who had beforehand been treated with long-acting insulin. It confirmed that Soliqua 100/33 might work a bit of better than Lantus hemoglobin A1c (HbA1c), but in addition not to lower blood sugar levels.

    After 30 weeks of remedy, Soliqua 100/33 lowered HbA1c by 1.1% and blood sugar fasting by fasting 5.7 mg / dl. During the same interval, Lantus lowered HbA1c by zero.6% and fasting blood glucose levels by 7.0 mg / dl

    Use with metformin

    In one other research, Soliqua 100/33 with metformin towards Lantus metformin in adults with t metformin. Sort 2 Diabetes. These individuals had previously been handled with metformin alone or with metformin and one other oral antidiabetic agent

    over 30 weeks with Soliqua 100/33 with metformin was slightly simpler than Lantus metformin. Soliqua 100/33 with metformin lowered HbA1c by 1.6% and fasting blood sugar by 59.1 mg / dl. In turn, Lantus and metformin decreased HbA1c by 1.three% and fasting blood sugar by 55.Eight mg / dl.

    Observe: It is very important keep in mind that both of these medicine reduces HbA1c or blood sugar ranges rely upon many elements resembling: you’re taking

  • how intently you comply with a remedy program
  • Value

    Soliqua 100/33 and Lantus are both brand names. There are at present no widespread types obtainable in either drug. Model medicine usually value more than generic medicine

    In response to GoodRx.com estimates, Lantus often costs less than Soliqua 100/33. The actual worth you’d pay for a drug will rely on your dose, your insurance coverage plan, your location and the pharmacy you’re utilizing.

    Soliqua 100/33 vs. Victoza

    Soliqua 100/33 incorporates two medicine: [19659048] insulin glargine, a long-acting insulin

  • lixisenatide, belonging to the glucagon-like peptide 1 (GLP-1) receptor agonist
  • Victoza accommodates the drugs of liraglutide, which can also be an agonist of the GLP-1 receptor. As a result of Soliqua 100/33 and Victoos have an lively ingredient in the same drug class, they work the same approach within the physique.

    Operation

    Soliqua 100/33 is FDA-approved to enhance blood glucose levels in adults with 2 diabetes.

    Victoza has also been authorised to improve blood sugar levels in adults with sort 2 diabetes combined with higher eating regimen and exercise. As well as, it has been authorised to scale back the danger of major heart disease akin to coronary heart assaults and stroke in individuals with sort 2 diabetes and heart illness. answer for disposable pen. Both medicines are injected underneath the pores and skin (subcutaneously) once a day.

    Aspect Results and Risks

    Because Soliqua 100/33 and Victoza include each medicine that belong to the GLP-1 class, each medicine may cause very comparable negative effects. Under are examples of those unwanted side effects. 19659048] Might happen with Soliqua 100/33:

    • hypoglycemia (low blood sugar)
    • respiratory infections akin to widespread chilly or flu
    • headache
  • Might Happen With Victosa:
    • decreased appetite
    • vomiting
    • constipation
    • stomach issues
  • Might occur with both Soliqua 100/33 and Victosa:
  • Critical Aspect Results

    These lists embrace examples of great uncomfortable side effects which will happen with Soliqua 100/33, Victosa, or both (taken individually).

    • Might occur with Soliqua 100/33:
      • hypokalemia (low potassium content material)
    • Might Happen With Victosa:
      • thyroid cancer *
      • gallbladder disease
    • Might occur with each Soliqua 100/33 and Victosa:
      • severe allergic reaction
      • severe hypoglycemia (severe low blood sugar)
      • pancreatitis (pancreatitis)
      • kidney injury

    * Victo has remedy for FDA thyroid most cancers. Enclosed Warning is the strongest warning the FDA requires.

    Efficacy

    Soliqua 100/33 and Victoza haven’t been instantly compared in medical studies, however both have been shown to be efficient within the remedy of Sort 2 diabetes

    . Erillisissä tutkimuksissa sekä Soliqua 100/33 että Victoza alensivat HbA1c-pitoisuutta ja paastoverensokeritasoa ihmisillä, joilla oli tyypin 2 diabetes.

    • Kliinisessä tutkimuksessa 30 viikon hoidon jälkeen Soliqua 100/33 alensi hemoglobiinia A1c (HbA1c). 1,1% ja paastoverensokerin taso 5,7 mg / dl
    • Muissa kliinisissä tutkimuksissa, yli 52 viikon hoidossa, Victoza alensi HbA1c-arvoa noin zero,Eight-1,1% ja paaston verensokeritasoa 15 – 26 mg / dl.

    Erillinen kliininen tutkimus osoitti, että Victoza pienensi suurten sydänvaivojen, kuten sydänkohtausten ja aivohalvauksen, riskiä 13 prosenttia. Tätä lopputulosta ei ole tutkittu Soliqua 100/33: n tutkimuksessa.

    Huomaa: On tärkeää muistaa, että kuinka hyvin kumpikaan näistä lääkkeistä alentaa HbA1c- tai verensokeritasoa riippuu monista tekijöistä, kuten:

    • verensokerisi, kun aloitat lääkkeen
    • ruokavalio- ja liikuntaohjelmasi
    • muut diabeteslääkkeet, joita otat
    • kuinka tarkasti noudatat hoito-ohjelmaa

    Kustannukset

    Soliqua 100/33 ja Victoza ovat molemmat tuotenimeä. Tällä hetkellä ei ole olemassa yleisiä muotoja, jotka ovat käytettävissä kummassakin lääkkeessä.

    GoodRx.comin arvioiden mukaan Victoza maksaa yleensä enemmän kuin Soliqua 100/33. Todelliset kustannukset, jotka maksaisitte jostakin lääkkeestä, riippuvat annoksestasi, vakuutussuunnitelmastasi, sijainnistasi ja käyttämästä apteekista.

    Soliqua 100/33 vs. Toujeo

    Soliqua 100/33 sisältää kaksi lääkettä: [19659048]insulin glargine, which is a long-acting insulin

  • lixisenatide, which belongs to class of medicine referred to as glucagon-like peptide 1 (GLP-1) receptor agonists
  • Insulin glargine is the drug contained in Toujeo. As a result of Soliqua 100/33 and Toujeo share an lively ingredient, they work in comparable methods inside the physique.

    Uses

    Soliqua 100/33 is FDA-approved to improve blood sugar levels in adults with sort 2 diabetes. It’s accepted for use with weight loss plan modifications and exercise.

    Toujeo is FDA-approved to enhance blood sugar levels in adults with sort 2 diabetes, and adults and youngsters with sort 1 diabetes.

    Drug types and administration

    Soliqua 100/33 and Toujeo each come as a liquid answer in a disposable injectable pen. Each medicine are self-injected beneath the skin (subcutaneous) once per day.

    Soliqua 100/33 is available in one amount. Each pen incorporates three mL of drug answer, with 300 models of insulin glargine and 100 mcg of lixisenatide. The utmost dose per injection is 60 models, which might imply 60 models of insulin glargine and 20 mcg lixisenatide.

    Toujeo comes in two totally different amounts:

    • Toujeo SoloStar incorporates 450 models of insulin glargine in 1.5 mL of answer, with a maximum dose of 80 models per injection.
    • Toujeo Max SoloStar incorporates 900 models of insulin glargine in three mL of answer, with a maximum dose of 160 models per injection.

    Unwanted side effects and dangers

    Soliqua 100/33 and Toujeo each share the same long-acting insulin, insulin glargine. Subsequently, each medicine may cause very comparable negative effects. Under are examples of those unwanted side effects.

    Extra widespread uncomfortable side effects

    These lists include examples of more widespread unwanted effects that may occur with Soliqua 100/33, with Toujeo, or with both medicine (when taken individually).

    • Can occur with Soliqua 100/33:
    • Can occur with Toujeo:
      • weight achieve
      • injection website reactions
      • lipodystrophy (indentation or melancholy at the space of injection)
      • itchiness
      • rash
      • swelling in your legs, ankles, or ft
    • Can happen with each Soliqua 100/33 and Toujeo:
      • respiratory infections such as the widespread chilly or flu
      • hypoglycemia (low blood sugar)

    Critical unwanted side effects

    These lists include examples of great negative effects that can happen with Soliqua 100/33, with Toujeo, or with both medicine (when taken individually).

    • Can happen with Soliqua 100/33:
      • pancreatitis (inflammation of the pancreas)
      • kidney injury
    • Can occur with Toujeo:
      • few distinctive critical negative effects
    • Can occur with both Soliqua 100/33 and Toujeo:
      • extreme allergic response
      • extreme hypoglycemia (severe low blood sugar)
      • hypokalemia (low potassium levels)

    Effectiveness

    Soliqua 100/33 and Toujeo haven’t been instantly in contrast in medical research. Nevertheless, individual studies have shown that both Toujeo and Soliqua 100/33 could be efficient in decreasing both HbA1c and fasting blood sugar levels.

    • In a medical research, Soliqua 100/33 lowered hemoglobin A1c (HbA1c) by 1.1 % and fasting blood sugar levels by 5.7 mg/dL after 30 weeks of remedy.
    • In other medical research, Toujeo decreased HbA1c by about zero.73 to 1.42 % and fasting blood sugar ranges by 18 to 61 mg/dL over 26 weeks of remedy.

    Observe: It’s necessary to needless to say how nicely both of those medicine would decrease your HbA1c or blood sugar levels would depend upon many elements, together with:

    • your blood sugar levels whenever you begin the drug
    • your weight loss plan and exercise regimens
    • the other diabetes drugs that you simply take
    • how intently you comply with your remedy routine

    Prices

    Soliqua 100/33 and Toujeo are both brand-name medicine. There are at present no generic varieties obtainable of either drug. Model-name drugs often value greater than generics.

    In response to estimates from GoodRx.com, Toujeo usually costs greater than Soliqua 100/33. The actual worth you’d pay for either drug would rely in your dose, your insurance coverage plan, your location, and the pharmacy you employ.

    Soliqua 100/33 vs. Adlyxin

    Soliqua 100/33 incorporates two medicine:

    • insulin glargine, which is a long-acting insulin
    • lixisenatide, which belongs to class of medicine referred to as glucagon-like peptide 1 (GLP-1) receptor agonists

    Lixisenatide can also be the drug contained in Adlyxin. As a result of Soliqua 100/33 and Adlyxin share an lively ingredient, they work in comparable ways within the body.

    Uses

    Soliqua 100/33 is FDA-approved for use with weight-reduction plan modifications and exercise to enhance blood sugar ranges in adults with sort 2 diabetes.

    Adlyxin is FDA-approved for use with weight-reduction plan and train to improve blood sugar ranges in adults with sort 2 diabetes.

    Drug types and administration

    Soliqua 100/33 and Adlyxin each come as a liquid answer in a disposable injectable pen. Both medicine are self-injected beneath the skin (subcutaneous) once per day.

    The Soliqua 100/33 pen is available in one amount. Each pen incorporates three mL of drug answer, with 100 models of insulin glargine and 33 mcg of lixisenatide per mL. The maximum dose per injection is 60 models, which would imply 60 models of insulin glargine and 20 mcg lixisenatide.

    The Adlyxin pen is available in two totally different quantities:

    • The green Adlyxin pen accommodates 50 mcg/mL in three mL of answer, with a dose of 10 mcg per injection.
    • The burgundy Adlyxin pen incorporates 100 mcg/mL in three mL of answer, with a dose of 20 mcg per injection.

    Unwanted effects and dangers

    Soliqua 100/33 and Adlyxin both include the drug lixisenatide. Subsequently, both drugs may cause very comparable uncomfortable side effects. Under are examples of these uncomfortable side effects.

    Extra widespread unwanted side effects

    These lists include examples of extra widespread uncomfortable side effects that can happen with Soliqua 100/33, with Adlyxin, or with each medicine (when taken individually).

    • Can happen with Soliqua 100/33:
      • respiratory infections resembling widespread cold or flu
    • Can happen with Adlyxin:
    • Can happen with each Soliqua 100/33 and Adlyxin:
      • nausea
      • diarrhea
      • headache
      • hypoglycemia (low blood sugar)

    Critical negative effects

    These lists include examples of great negative effects that may happen with Soliqua 100/33, with Adlyxin, or with each medicine (when taken individually).

    • Can happen with Soliqua 100/33:
      • hypokalemia (low potassium ranges)
    • Can occur with Adlyxin:
      • few unique critical negative effects
    • Can happen with both Soliqua 100/33 and Adlyxin:
      • extreme allergic response
      • severe hypoglycemia (extreme low blood sugar)
      • pancreatitis (inflammation of the pancreas)
      • kidney injury

    Effectiveness

    Using both Soliqua 100/33 or Adlyxin as a single-drug remedy for Sort 2 diabetes has not been instantly compared in medical analysis. Nevertheless, using each drug in combination with metformin (an oral diabetes drug) has been immediately in contrast.

    Separate research when used alone

    In separate medical research, Soliqua 100/33 and Adlyxin have been each efficient alone in decreasing fasting blood sugar in those with sort 2 diabetes.

    • In a medical research, Soliqua 100/33 lowered hemoglobin A1c (HbA1c) by 1.1 % and fasting blood sugar ranges by 5.7 mg/dL after 30 weeks of remedy.
    • In a special medical research, Adlyxin lowered HbA1c by 0.57 to 0.71 % and fasting blood sugar levels by 4.48 to 24.56 mg/dL over 24 weeks of remedy.

    Direct comparison when used with metformin

    One other research examined using Soliqua 100/33 with metformin instantly towards using Adlyxin with metformin in adults with Sort 2 diabetes. The individuals within the research had been previously treated with metformin alone, or with metformin and one other oral diabetes drug.

    After 30 weeks, Soliqua 100/33 with metformin was simpler than Adlyxin with metformin. Soliqua 100/33 with metformin lowered HbA1c by 1.6 % and fasting blood sugar levels by 59.1 mg/dL. Adlyxin and metformin, however, decreased HbA1c by zero.9 % and fasting blood sugar levels by 27.2 mg/dL.

    Notice: It’s necessary to remember that how nicely both of these medicine would decrease your HbA1c or blood sugar ranges would depend upon many elements, together with:

    • your blood sugar ranges once you start the drug
    • your weight loss plan and train regimens
    • the opposite diabetes drugs that you simply take
    • how intently you comply with your remedy regimen

    Costs

    Soliqua 100/33 and Adlyxin are each brand-name medicine. There are at present no generic varieties obtainable of either drug. Model-name drugs often value more than generics.

    In accordance with estimates from GoodRx.com, Adlyxin usually prices more than Soliqua 100/33. The actual worth you’d pay for either drug would depend on your dosage, your insurance plan, your location, and the pharmacy you employ.

    Soliqua 100/33 uses

    The Meals and Drug Administration (FDA) approves prescribed drugs corresponding to Soliqua 100/33 to treat certain circumstances. Soliqua 100/33 is FDA-approved for use with weight-reduction plan modifications and exercise to enhance blood sugar levels in adults with Sort 2 diabetes.

    In a 30-week medical research of people that had been handled with a kind of basal insulin (comparable to insulin glargine), Soliqua 100/33 was found to be effective. It decreased hemoglobin A1c (HbA1c)by 1.1 % and fasting blood sugar levels by 5.7 mg/dL.

    A 30-week medical research targeted on individuals who had been handled with metformin alone, or with metformin and another oral diabetes drug. For the individuals in the research, Soliqua 100/33 and metformin lowered their HbA1c by 1.6 % and fasting blood sugar levels by 59.1 mg/dL.

    Soliqua 100/33 use with different medicine

    Soliqua 100/33 can be used alone or together with different medicine to improve blood sugar ranges in individuals with Sort 2 diabetes. In diabetes remedy, it’s typical for multiple treatment for use to regulate blood sugar ranges if one drug alone hasn’t improved blood sugar levels sufficient.

    Examples of medicine that can be utilized with Soliqua 100/33 embrace:

    • canagliflozin (Invokana)
    • dapagliflozin (Farxiga)
    • glimepiride (Amaryl)
    • glipizide (Glucotrol)
    • glyburide (DiaBeta, Glynase)
    • metformin (Glucophage, Glumetza, Riomet)
    • pioglitazone (Actos)

    Soliqua 100/33 and alcohol

    Avoid consuming an excessive amount of alcohol whereas taking Soliqua 100/33. Alcohol can change your blood sugar ranges and improve your danger of hypoglycemia (low blood sugar) and pancreatitis(infected pancreas).

    For those who drink alcohol, speak to your physician about how much alcohol is protected for you.

    Soliqua 100/33 interactions

    Soliqua 100/33 can interact with several other drugs. It might additionally interact with certain dietary supplements in addition to certain meals.

    Totally different interactions may cause totally different results. For example, some can intrude with how nicely a drug works, while others may cause elevated unwanted effects.

    Soliqua 100/33 and different drugs

    Under is an inventory of medications that can interact with Soliqua 100/33. This listing doesn’t include all medicine which will work together with Soliqua 100/33.

    Earlier than taking Soliqua 100/33, make sure you tell your doctor and pharmacist about all prescription, over-the-counter, and different medicine you’re taking. Additionally inform them about any nutritional vitamins, herbs, and dietary supplements you employ. Sharing this info may help you avoid potential interactions.

    If in case you have questions on drug interactions which will have an effect on you, ask your doctor or pharmacist.

    Different diabetes drugs

    Taking Soliqua 100/33 with different diabetes drugs can result in severely low blood sugar levels and improve your danger of hypoglycemia (low blood sugar). When you take any of those drugs, you might have to examine your blood sugar levels more typically. Additionally, your doctor may have to vary your dosage of Soliqua 100/33.

    Examples of diabetes drugs embrace:

    • canagliflozin (Invokana)
    • dapagliflozin (Farxiga)
    • empagliflozin (Jardiance)
    • glyburide (DiaBeta, Glynase, Micronase)
    • glimepiride (Amaryl)
    • glipizide (Glucotrol)
    • meal-time insulins (Humalog, Novolog)
    • metformin (Glucophage)
    • nateglinide (Starlix)
    • repaglinide (Prandin)

    As well as, utilizing Soliqua 100/33 with diabetes medicine referred to as thiazolidinediones (TZDs) may cause fluid retention. It might also improve your danger of heart failure or worsen signs of heart failure (see warning under). Examples of these medicine embrace:

    • pioglitazone (Actos)
    • rosiglitazone (Avandia)

    TZDS and Heart Failure Warning

    Hypertension drugs

    Taking Soliqua 100/33 with sure hypertension drugs can lead to severely low blood sugar levels and improve your danger of hypoglycemia (low blood sugar). When you take any of these drugs, chances are you’ll have to examine your blood sugar levels more typically. Additionally, your doctor may have to vary your dosage of Soliqua 100/33.

    Examples of hypertension drugs that may improve the danger of hypoglycemia when taken with Soliqua 100/33 embrace:

    • angiotensin-converting enzyme (ACE) inhibitors, comparable to:
      • benazepril (Lotensin)
      • captopril
      • enalapril (Vasotec)
      • lisinopril (Zestril)
    • angiotensin II receptor blockers (ARBs), comparable to:
      • valsartan (Diovan)
      • candesartan (Atacand)
      • irbesartan (Avapro)
      • losartan (Cozaar)
      • olmesartan (Benicar)

    Other blood strain drugs can masks the symptoms of extreme low blood sugar levels. These medicine may additionally improve or lower how efficient Soliqua 100/33 is at decreasing blood sugar levels. In the event you take these drugs with Soliqua 100/33, you could have to verify your blood sugar levels extra typically. Additionally, your physician may have to vary your dosage of Soliqua 100/33.

    Examples of blood strain drugs that may masks the indicators of low blood strain or affect how properly Soliqua 100/33 works embrace:

    • clonidine (Catapres)
    • metoprolol (Lopressor, Toprol-XL)
    • atenolol (Tenormin)

    Other medicine which will cover signs of hypoglycemia

    Some drugs can mask the indicators and signs of extreme low blood sugar ranges. In the event you take these drugs, chances are you’ll have to examine your blood sugar levels extra typically. Also, your physician may have to vary your dosage of Soliqua 100/33.

    Examples of those drugs embrace:

    • albuterol (ProAir, Proventil, Ventolin)
    • guanethidine
    • reserpine

    Different drugs that can lower blood sugar levels

    Taking Soliqua 100/33 with sure other drugs can result in severely low blood sugar ranges and improve your danger of hypoglycemia (low blood sugar). Should you take any of these drugs, you could have to examine your blood sugar levels more typically. Additionally, your physician may have to vary your dosage of Soliqua 100/33.

    Examples of those drugs embrace:

    • disopyramide (Norpace)
    • certain cholesterol drugs, similar to fenofibrate (Tricor, Triglide) and gemfibrozil(Lopid)
    • sure antidepressants, corresponding to fluoxetine (Prozac, Sarafem) and selegiline (Emsam, Zelapar)
    • octreotide (Sandostatin)
    • sulfamethoxazole-trimethoprim (Bactrim, Septra)

    Different drugs that improve your blood sugar ranges

    Some drugs can improve blood sugar ranges in your physique. Should you take these drugs, you could have to examine your blood sugar levels more typically to stop hyperglycemia (excessive blood sugar). Also, your doctor may have to vary your dosage of Soliqua 100/33.

    Examples of these drugs embrace:

    • albuterol (ProAir, Proventil, Ventolin)
    • sure antivirals, reminiscent of atazanavir (Reyataz) and lopinavir/ritonavir (Kaletra)
    • certain steroids, comparable to budesonide (Entocort EC, Pulmicort, Uceris), prednisone, and fluticasone (Flonase, Flovent)
    • certain diuretics, comparable to chlorothiazide (Diuril) and hydrochlorothiazide (Microzide)
    • certain antipsychotics, corresponding to clozapine (Clozaril, Fazaclo) and olanzapine (Zyprexa)
    • sure hormones, akin to danazol (Danazol), levothyroxine (Levoxyl, Synthroid) and somatropin (Genotropin)
    • glucagon (GlucaGen)
    • niacin (Niaspan, Slo-Niacin, others)
    • oral contraceptives (contraception tablets)

    Medicine that improve or lower the consequences of Soliqua 100/33

    Some drugs can affect how Soliqua 100/33 works in your physique. For those who take these drugs, you might have to examine your blood sugar ranges extra typically. Also, your doctor may have to vary your dosage of Soliqua 100/33.

    Examples of these drugs embrace:

    • albuterol (ProAir, Proventil, Ventolin)
    • lithium

    Soliqua 100/33 and herbs and dietary supplements

    Taking Soliqua 100/33 with sure herbs or supplements may improve your danger of hypoglycemia (low blood sugar ranges). Examples of these embrace:

    • alpha-lipoic acid
    • banaba
    • bitter melon
    • chromium
    • gymnema
    • prickly pear cactus
    • white mulberry

    How Soliqua 100/33 works

    Soliqua 100/33 helps enhance blood sugar ranges in individuals with Sort 2 diabetes.

    How insulin affects blood sugar

    Usually, once you eat food, your physique releases a hormone referred to as insulin. Glucose (sugar) from the food travels to your bloodstream, and the insulin helps transport it into the cells of your physique. The cells then turn the glucose into power.

    Individuals with Sort 2 diabetes often have insulin resistance. This means their physique doesn’t reply to insulin the best way it ought to. Over time, individuals with sort 2 diabetes may additionally stop producing sufficient insulin.

    When your body doesn’t reply to insulin the best way it ought to, or if it doesn’t produce enough insulin, this causes issues. The cells of your physique might not get the glucose they need to work appropriately.

    Additionally, you might get an excessive amount of glucose in your blood. That is referred to as hyperglycemia (high blood sugar). Having an excessive amount of glucose in your blood can injury your body and organs, including your eyes, heart, nerves, and kidneys.

    What Soliqua 100/33 does

    Soliqua 100/33 incorporates two medicine. These are insulin glargine, which is a long-acting insulin, and lixisenatide, which is a glucagon-like peptide 1 (GLP-1) receptor agonist.

    Insulin glargine works in a method: it lowers your blood sugar levels by shifting glucose from your bloodstream into your cells.

    Lixisenatide works in 3 ways. First, it increases the quantity of insulin your physique makes. This increased insulin helps move extra glucose out of your bloodstream and into your cells. Second, it causes your stomach to empty more slowly after a meal, making you are feeling full longer. And third, it tells your liver to release much less glucose into your blood.

    How long does it take to work?

    Soliqua 100/33 begins to work proper after you inject it. Nevertheless, it reaches its highest effect of about 2.5 to 3 hours after every injection.

    Soliqua 100/33 and pregnancy

    Research knowledge is restricted for use of Soliqua 100/33 during pregnancy in people. Nevertheless, animal studies present that there could also be danger of start defects with use of lixisenatide throughout being pregnant. Lixisenatide is likely one of the medicine found in Soliqua 100/33. Subsequently, Soliqua 100/33 ought to solely be used during pregnancy if the potential benefit outweighs the potential risks.

    When you’re pregnant or planning to grow to be pregnant, speak together with your doctor concerning the dangers and advantages of using Soliqua 100/33 throughout being pregnant.

    Soliqua 100/33 and breastfeeding

    It isn’t recognized if Soliqua 100/33 passes into breast milk. Before breastfeeding, you need to talk about together with your physician the dangers and advantages of taking this drug whereas breastfeeding.

    Widespread questions about Soliqua 100/33

    Listed here are solutions to some often requested questions on Soliqua 100/33.

    Does Soliqua 100/33 cause weight achieve?

    In medical trials, Soliqua 100/33 was not discovered to cause weight achieve. In reality, in a single medical research, people who took Soliqua 100/33 for 30 weeks misplaced about 1.5 kilos.

    It’s fascinating to note that the person medicine contained in Soliqua 100/33 appear to have differing results on weight. One of the medicine is insulin glargine, which is a long-acting insulin. Sometimes, medicine containing insulin have been linked with weight achieve.

    Nevertheless, the opposite drug in Soliqua 100/33 known as lixisenatide, which is a glucagon-like peptide 1 (GLP-1) receptor agonist. Drugs within the GLP-1 drug class have shown weight reduction as a aspect impact in numerous medical studies.

    For those who’re involved concerning the effects that Soliqua 100/33 may need on your weight, speak together with your doctor.

    Is Soliqua 100/33 insulin?

    Sure, Soliqua 100/33 incorporates insulin. Soliqua 100/33 is made from two medicine, one among which is insulin glargine, long-acting insulin.

    The second drug is lixisenatide, which is a glucagon-like peptide 1 (GLP-1) receptor agonist.

    Is Soliqua 100/33 long-acting?

    Sure. Soliqua 100/33 accommodates two lively medicine. Considered one of these is insulin glargine, which is a long-acting insulin.

    Can Soliqua 100/33 be used to deal with sort 1 diabetes?

    No, Soliqua 100/33 shouldn’t be used to treat sort 1 diabetes. Soliqua 100/33 has not been studied nor accredited by the Food and Drug Administration to deal with that situation. It’s only authorised to deal with sort 2 diabetes.

    Soliqua 100/33 warnings

    Before taking Soliqua 100/33, speak together with your doctor about your well being history. Soliqua 100/33 will not be right for you when you’ve got certain medical circumstances. These embrace:

    • Kidney disease. In case you have kidney disease, taking Soliqua 100/33 might worsen your situation. In case your condition worsens, you could have to stop taking Soliqua 100/33. Don’t take this medicine if in case you have severe kidney disease.
    • Sluggish stomach emptying. Lixisenatide, one of the medicine in Soliqua 100/33, slows the motion of your stomach muscular tissues. When you have gastroparesis, which suggests your body digests food slowly, taking Soliqua 100/33 might worsen your situation. Individuals with extreme gastroparesis shouldn’t take this medicine.
    • Pancreas or gallbladder issues, or alcohol use dysfunction. Soliqua 100/33 might improve your danger of pancreatitis. You could be at larger danger of pancreatitis when you’ve got a history of pancreatitis, gallbladder stones, or alcoholism. If in case you have a history of those problems, speak together with your physician about whether or not Soliqua 100/33 is true for you.

    Soliqua 100/33 overdose

    Taking an excessive amount of of this medicine can improve your danger of great unwanted side effects.

    Overdose symptoms

    Symptoms of an overdose can embrace:

    • extreme hypoglycemia (extreme low blood sugar), which may cause shakiness, nervousness, and confusion
    • hypokalemia (low potassium levels), which may cause weak spot, constipation, and muscle cramps
    • gastrointestinal issues, which may cause diarrhea, nausea, and vomiting

    What to do in case of overdose

    For those who assume you’ve taken too much of this drug, name your physician or search steerage from the American Affiliation of Poison Control Facilities at 800-222-1222 or by means of their online device. But if your symptoms are severe, name 911 or go to the closest emergency room immediately.

    Soliqua 100/33 expiration and storage

    When Soliqua 100/33 is allotted from the pharmacy, the pharmacist will add an expiration date to the label on the container. This date is usually one yr from the date the medicine was allotted.

    The purpose of such expiration dates is to guarantee the effectiveness of the medicine throughout this time. The current stance Trusted Source of the Food and Drug Administration (FDA) is to keep away from using expired drugs.

    How lengthy a medicine stays good can rely upon many elements, together with how and where the medicine is stored. Store your Soliqua 100/33 pens in your fridge, at a temperature between 36°F and 46°F (2°C and eight°C). By no means freeze your pens.

    After the primary use of every pen, you’ll be able to retailer it at room temperature (77°F/25°C), however be sure you shield it from mild. Discard each pen after 28 days from its first use.

    When you’ve got unused medicine that has gone past the expiration date, speak to your pharmacist about whether or not you may still have the ability to use it.

    Professional info for Soliqua 100/33

    The next info is offered for clinicians and other healthcare professionals.

    Indications

    Soliqua 100/33 is FDA-approved for use with weight loss plan and train to improve glycemic control in adults with Sort 2 diabetes mellitus.

    Mechanism of motion

    Soliqua 100/33 is a mixture of insulin glargine (a basal insulin analog) and lixisenatide (a glucagon-like peptide 1 [GLP-1] receptor agonist).

    Insulin glargine lowers blood glucose by growing peripheral glucose uptake and decreasing glucose production from the liver. Lixisenatide reduces blood glucose by growing insulin secretion, reducing glucagon secretion, and slowing gastric emptying.

    Pharmacokinetics and metabolism

    The insulin glargine-to-lixisenatide ratio has no influence on the pharmacokinetics of both element.

    Insulin glargine doesn’t have a peak and is metabolized partially at the carboxyl terminus of the B chain in the subcutaneous depot.

    Time to max focus for lixisenatide is 2.5 to three hours. Lixisenatide has a 55 % protein binding fee and is eradicated by way of urine and proteolytic degradation. Imply half-life is about 3 hours.

    Contraindications

    Soliqua 100/33 is contraindicated in patients:

    • throughout hypoglycemic episodes
    • with a historical past of extreme hypersensitivity to insulin glargine or lixisenatide

    Storage

    Soliqua 100/33 pens must be saved in a fridge, at a temperature between 36°F and 46°F (2°C and eight°C), but by no means frozen. After the primary use, pens could be saved at room temperature 77°F (25°C). They need to be shielded from mild. Discard the pen after 28 days from first use.

    Disclaimer: Healthline has made each effort to make certain that each one info is factually right, complete, and up-to-date. Nevertheless, this article should not be used in its place for the information and experience of a licensed healthcare skilled. You need to all the time consult your doctor or one other healthcare professional earlier than taking any medicine. The drug info contained herein is subject to vary and is not meant to cover all attainable makes use of, directions, precautions, warnings, drug interactions, allergic reactions, or opposed results. The absence of warnings or different info for a given drug does not indicate that the drug or drug mixture is protected, efficient, or applicable for all sufferers or all specific uses.